BONUS BIOGROUP (TASE: BONS) is a biotechnology company applying proprietary, innovative technology to supply tissue-engineered viable bone grafts. 

The company strives to become a world leader in the field of tissue engineering and live bone transplantation.

News and Press Release

  • Wednesday, 22 January 2020 17:24
    Confirmation of issued patent in Europe, which in concert with the issued patents in the USA and Australia, provides Bonus BioGroup the exclusive rights for the commercialization in 70% of the world population with a high income profile1, in a world market estimated at USD 8 billion
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  • Sunday, 02 September 2018 17:24
    Bonus BioGroup raises investment in the amount of NIS 18 million (USD 5 million), at a price of 60 Agorot per share
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  • Wednesday, 08 August 2018 08:25
    Bonus BioGroup Secures Exclusivity in the U.S. over Manufacturing and Commercialization of Live Bone Graft
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  • Friday, 02 March 2018 17:31
    For the first time ever, arm and leg were healed using a bone graft grown outside patient’s body, in an orthopedic clinical trial for filling extensive critical bone void in limbs
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  • Wednesday, 20 December 2017 08:15
    For the first time ever, bone graft grown outside patient’s body is implanted in his leg, in an orthopedic clinical trial for filling extensive critical bone defects in limbs
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Bonus BioGroup has developed a novel method to grow bone grafts from cells derived from the patient's fat tissue. The graft is precisely fit to the injured bone site and rapidly integrates in the patient's body.

BonoFillTM products family 
Exclusive 3D, high-density bone grafts, grown from the cells derived from the patient's fat tissue, obtained in a simple procedure. Heterogeneous population of cells are then cultured and expanded in a bioreactor system, on a supportive matrix (scaffold), and induced to generate the bone graft. The graft is precisely fit to the injured bone site and rapidly integrates in the patient's body.

Injectable bone graft


Anatomically pre-designed bone graft


Appropriate for defined defects, such as maxillofacialbone voids and cysts.

A cut to shape graft, match the dimensions of the patient's bone gap, determine using CT imaging

Clinical Trial


In August, 2017 Bonus announced the first live human bone graft, grown outside the patient's body, transplanted into a patient’s arm as part of a clinical trial for reconstruction of extensive critical bone loss in bones of the extremities.

Maxillofacial Bone Regeneration

Bonus BioGroup commenced a clinical trial to evaluate the safety and efficacy of BonoFillTM in the treatment of human maxillofacial bone deficiency. BonoFillTM is regulated under the category of Advanced Therapy Medicinal Product (ATMP) that complies with the definition of Somatic Cell Therapies, and was developed according to GMP and GCP principles.



Bone reconstruction is medically required to repair an injured bone arise in a multitude of situations of trauma and bone diseases. The ideal bone graft is biocompatible, functionally and structurally similar to the patient's bone, easily transplantable and cost-effective. Failure rates of current techniques have encouraged researchers to seek new biomaterials promoting bone regeneration.

Adipose tissue has significant advantages as a cell source for tissue engineering products. Human Adipose Tissue-Derived Cells (HATDCs) can differentiate along multiple cell lineage pathways to form various types of mature cells, and can be safely and effectively transplanted back into the patient.

The Forefront of Tailored Medicine

Get In Touch

Bonus BioGroup Ltd.

Matam Advanced, Technology Park, P.O.B 15143 Haifa 31905 Israel

+972 (0)73 206 7104


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