Product Pipeline

Product

Preclinical phase

Clinical phase

Clinical Trial Phase I/II
BonoFill bone graft for maxillofacial applications

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BonoFillTM is a viable, autologous bone graft, manufactured from the patient’s cells, and designed to induce and enhance the bone regeneration process without the risk of immune rejection or surgical failure. BonoFillTM is currently being evaluated in a phase I/II clinical trial as an injectable bone graft for the reconstruction of bone deficiencies in the maxillofacial indication. 

Clinical Trial Phase I/II
BonoFill bone graft for orthopedic applications

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BonoFillTM is a viable, autologous bone graft, manufactured from the patient’s cells, and designed to induce and enhance the bone regeneration process without the risk of immune rejection or surgical failure. BonoFillTM is currently being evaluated in a phase I/II clinical trial as an injectable bone graft for the reconstruction of orthopedic bone deficiencies in short and long bones of the extremities.

Clinical Trials Phase I/II
MesenCure – COVID-19 therapy

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Bonus BioGroup is invested in the effort to develop a cell-based drug product, MesenCure, for the treatment of COVID-19 patients with life-threatening acute respiratory distress.

A phase I/II clinical trial with MesenCure is currently conducted at the largest medical center in the north of Israel.

Preclinical Trials
Novel nanomaterials technology for tissue regeneration:

ProductPipelinellogos3The development of nanomaterials for tissue regeneration is a project jointly undertaken by Bonus BioGroup and the USA-based company, Cellora LLC. Cellora is developing nanoparticle composites for local vascularization of ischemic tissues, which enhance angiogenic activity and stimulate the body’s natural repair mechanism to promote tissue regeneration. The project is focusing on the integration of Cellora's novel nanomaterials with Bonus BioGroup's products for tissue engineering applications.


The novel technology enables the regeneration of both hard and soft tissue inside the patient’s body, allowing it to serve as a substitute in a variety of medical applications, precluding the need for external production of a cell-based graft. By integrating this technology, Bonus BioGroup will be able to develop and produce a variety of off-the-shelf products that do not require patient compatibility.

The project, supported by BIRD Foundation, is carried out in Cellora LLC in collaboration with Harvard-MIT Biomedical Engineering Center (BMEC) under the Division of Health Sciences and Technology (HST), and at the Research and Development headquarters of Bonus BioGroup in Haifa, Israel.

Bonus BioGroup is exclusively entitled to carry out any action to commercialize and market the developed shelf products worldwide.

Preclinical Trials
Large vascularized bone graft:

ProductPipelinellogos4Bonus BioGroup is collaborating with researchers at the Technion – Israel Institute of Technology and in the Galil Medical Center, to develop a novel scaffold consisting of large capillary networks. This platform will assist cell growth and vascularization by mimicking the structure of blood vessels within the body. This technology aims to provide efficient physiological diffusion of oxygen and nutrients throughout the bone graft and to enable the regeneration of large bone deficiencies.

Repair of large bone defects remains challenging, despite significant advances in tissue engineering technology. The major limitation of current solutions lies in the poor transport of essential growth factors throughout the entire volume of the new graft, particularly to its center. Many efforts are being directed towards development of an optimal scaffold that can support bone cells, provide mechanical cues and ensure sufficient oxygen, nutrients and desired stimuli throughout the graft.

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