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Bonus BioGroup (TASE: BONS) is a biotechnology company applying a proprietary, innovative technology to generate viable tissue-regenerating bone grafts. The company strives to become a world leader in the field of tissue engineering and live bone transplantation.

A unique method for growing a three dimensional (3D) high-density live bone graft – BonoFillTM, was developed by the company. BonoFillTM is derived from the patient's own (autologous) cells. BonoFillTM is constructed of a variety of cells which are grown in multi-layers within a bioreactor system. This unique technology enables construction of the bone graft outside of the human body (ex vivo), and promotes graft acceptance by the patient's body, following transplantation. It also allows, for the first time, growth of a human tissue graft tailored to the biological, physical and clinical needs of each patient, without invoking immune reactions or graft rejection.

The company was founded to commercialize over ten years of bone regeneration research carried out by Dr. Shai Meretzki, the founder and former CEO of Pluristem Therapeutics Inc. (NASDAQ: PSTI; TASE: PLTR), in cooperation with leading scientists from the Technion – Israel Institute of Technology, Rambam Health Care Campus and other prominent institutions.

Bonus BioGroup is targeting a multi-billion dollar worldwide market for the treatment of skeletal disorders such as bone- and cartilage-related arthritis and various types of bone and joint trauma (e.g., hip fractures, knee injuries).

A clinical trial was launched in April 2014 to evaluate the safety and efficacy of the company's live human bone grafts for the repair of maxillofacial bone deficiency, including upper and lower jawbone cavitation. These grafts are comprised of autologous adipose (fat) tissue cells.

Bonus BioGroup’s manufacturing facility is located within the company's complex in Haifa, Israel, and supplies the company in its clinical trials. The facility, as well as all the company's clinical and R&D activities, including the development stage, production, quality control and product supply, is Good Manufacturing Practice (GMP) and ISO-9001 certified.

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Management Team


Board of Directors

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Shai Meretzki, PhD
Chief Executive Officer and President
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Yossi Rauch, MBA
Chairman of the Board
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Avi Slonim, LLB, M.Ec
Non-Executive Director
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Mr. Daniel Benlolo
Non-Executive Director
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Mr. Gil Shapira
Non-Executive Director
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Yehuda Reznik, CPA
Non-Executive Director
 

 

Scientific Advisory Board

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Prof. Nimrod Rozen, MD, PhD

Prof. Rozen is the Head of the Department of Orthopedic Surgery at HaEmek Medical Center, Afula. He is the Founder of the Institute for Bone Repair at Rambam Health Care Campus, Haifa, and the Head of the Department of Orthopedic and Traumatology at Zvulun Medical Center, Haifa.

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Prof. Yehuda Ullman, MD

Prof. Ullman is the Head of the Department of Plastic and Reconstructive Surgery, the Burn Unit and the Aesthetic Plastic Surgery Service at Rambam Health Care Campus. He is a graduate of the Rappaport Faculty of Medicine at the Technion– Israel Institute of Technology, Haifa, and obtained clinical training at the Department of Plastic and Reconstructive Surgery at Rambam Health Care Campus. He completed a Fellowship program at Eastern Virginia Medical School in Norfolk, Virginia.

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Dr. Ephraim Tzur, DMD

Dr. Tzur is a senior periodontal surgeon specializing in implant surgery and cranio-maxillofacial rehabilitation and is the former Director of the Oral & Maxillofacial Surgery Unit at Assaf Harofeh Medical Center. He earned his medical degree from Hadassah University School and is board certified by the Israeli Board of Dental Surgeons. Dr. Tzur is a member of the Israeli and American Oral and Maxillofacial Surgeons. He has over 30 years of experience in all aspects of reconstruction and rehabilitation of hard and soft tissue defects of the oral cavity, jaws and facial structures. He is actively involved in dent-alveolar surgery, orthogenetic surgery for the treatment of congenital and developmental deformities, reconstruction of disease- and trauma-induced defects and in dental implantology for the regeneration and restoration of the jawbones.